Tyrian will kill Qrow and take out Ruby's eye. Ruby will then be taken to Salem where she will learn more of the truth, whilst Jaune will attempt to go and save her. This will begin to solidify rubyxjaune, though Ren and Nora may be distracted by the Grimm they've been teasing for a while.
I'm thinking Qrow will be killed by Tyrian here, because he's ultimately fulfilled his role as Ruby's guardian. Once this is done, it's standard for the mentor to be removed to allow for the protagonist to shine. Reasons why I think this will happen are because up until now, Cinder has been the hateable villain, yet we're beginning to see that she may have a redemption arc. This means we need a new person to fill the role, and Qrow's killer would be a perfect match. Additionally, this makes room for Hazel to become good after being swayed by Siera (don't know how to spell it), Cinder to kill Watts, and Ruby to kill Tyrian. This would actually make the reason for having an Elite Four group make sense as it resolves a lot of character arcs. Any secrets that die with Qrow will probably be revealed through Raven now instead, and her story could pretty much go to anyone except Weiss at the moment. (Also they put a lot of story and design into this location - and that tends to mean it's going to be pretty iconic to the story).
As for why Ruby will lose her eye, well there've been a lot of hints both within and outside the series itself (Kim kinda suggested it would happen in one of her streams :P). Also, it's long been known that losing an eye makes you more badass, and Ruby could always do with some more badassery as she grows older and more used to this world which was far darker than any of us expected.
Finally, I'm sure I've explained why Ruby and Jaune will probably end up together before, but I'm always happy to do it again (though I'll keep it brief this time). Basically, Jaune has two main options from here on out: fight Cinder to the death, leading to both of them being killed (both avenging Pyhrra and fulfilling his own Joan of Arc story by dying in fire) OR he can end up with Ruby, giving the healthy message of not letting people be held down by the past and learning to move on in order to find happiness, whilst probably at least choosing to spare Cinder.
Not sure what's gonna happen with the Grimm that keeps being mentioned, but it could be what leads to Nora dying, Ren avenging her and his family, before committing suicide. Happy stuff.
